Associate Scientist - In Vitro Neurobiology

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Associate Scientist- In Vitro Neurobiology

What You Will Do

Let’s do this. Let’s change the world. Amgen’s cardiometabolic team is an innovative target discovery and translational research unit with a focus on identifying novel targets for development of game-changing therapies for patients with obesity and associated cardiometabolic diseases. We employ advanced computational biology, state-of-the-art discovery screening technologies, genetics, and human-centric cell systems to dissect pathophysiology and identify novel drug targets.

This laboratory-based position will focus on cell culture support for the development of large-scale qualitative and quantitative functional genomics screens utilizing human derived central nervous system (CNS) models. There is an overarching aim to characterize genes and genetic regulatory circuits involved in the control of cellular metabolism and advance discovery projects by performing in vitro experiments under partial supervision.

Key Responsibilities:

• Work in an in vitro setting using aseptic technique, passaging, expansion, cryopreservation, assessment of cell-line quality, and cell characterization
• Maintain mammalian cell cultures derived from iPSC and/or primary neuronal or glial models
• Utilize functional cell-based assays and support in the development of immunoassays (western blot, ELISA, flow cytometry, immunofluorescence staining), fluorescent microscopy, and other imaging methods
• Operate and maintain standard lab equipment
• Document experimental plans and procedures timely with attention to detail
• Exhibit self-motivation and proactive attitude in designing and conducting experiments using state-of-the-art technologies
• With some supervision, plan, conduct or monitor experiments, record and organize data, analyze results, troubleshoot, and generate robust and reliable data

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a team player with these qualifications.

Basic Qualifications:

Master’s degree and 1 year of related scientific experience

OR

Bachelor’s degree and 3 years of related scientific experience

Preferred Qualifications:

• At least 3 years of mammalian cell culturing experience
• Demonstrated experience using assay technologies (e.g., luminescence, fluorescence, TR-FRET, AlphaLISA or high-content systems).
• Experience performing molecular biology experiments (such as RNA, DNA extraction, qPCR, cloning, CRISPR/Cas9-based genome editing) or performing antibody-based experiments (flow cytometry, ELISA, immunofluorescence imaging and western blot).
• Hands-on experience in handling samples in 96-well format is preferred
• Familiarity with Metabolic Disease Pathophysiology
• Strong organizational, analytical, and problem-solving skills
• Proficiency in GraphPad Prism, Microsoft Word, Excel, and PowerPoint

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and