Principal Clinical Scientist

Alignerr
Chicago, US
Remote

Job Description

Principal Clinical Scientist (AI Training)

About The Role

What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI understands medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting‑edge AI systems — helping ensure these models reason about clinical evidence the way a seasoned scientist would.

This is a fully remote, flexible contract role built for experienced clinical researchers who want to work at the intersection of science and frontier AI. No AI background required — just deep clinical expertise and a sharp eye for scientific rigor.

  • Organization: Alignerr
  • Type: Hourly Contract
  • Location: Remote
  • Commitment: 10–40 hours/week

What You'll Do

  • Design and review clinical trial protocols used to generate high-quality, regulator‑ready datasets for AI training and evaluation
  • Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
  • Evaluate AI‑generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations
  • Provide expert feedback that directly shapes how AI models understand, reason about, and evaluate clinical trial data and outcomes
  • Flag gaps in methodology, data quality, or regulatory relevance across AI‑generated clinical content

Who You Are

  • Senior‑level clinical researcher with hands‑on experience designing trial protocols for regulatory submission
  • Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies
  • Strong grounding in clinical research methodology, biostatistics, or translational science
  • Naturally rigorous — you hold AI‑generated outputs to the same standard you'd apply in a real submission
  • Self‑directed and comfortable working independently in an asynchronous environment

Nice to Have

  • Prior experience with data annotation, data quality evaluation, or AI output assessment
  • Background in pharmacology, oncology, rare disease, or another specialized therapeutic area
  • Familiarity with ICH guidelines, GCP standards, or regulatory submission frameworks
  • Experience working across multidisciplinary research teams

Why Join Us

  • Work directly on frontier AI systems that are reshaping how clinical and biomedical research is conducted
  • Influence how AI understands and evaluates real‑world clinical evidence — at a scale no individual trial could achieve
  • Fully remote and flexible — work when and where it suits you
  • Freelance autonomy with the structure of meaningful, high‑impact, task‑based work
  • Collaborate with world‑leading AI research labs on problems that matter
  • Potential for ongoing work and contract extension as new projects launch

Skills & Requirements

Technical Skills

Clinical trialsRegulatory-grade dataAiClinical research methodologyBiostatisticsTranslational scienceRigorIndependenceMedicineAiClinical research

Employment Type

CONTRACT

Level

principal

Posted

4/29/2026

Apply Now

You will be redirected to Alignerr's application portal.

Sign in and we'll score your resume against this role.