Principal Research Scientist - Drug Discovery

Our client, a world-renowned biopharmaceutical company at the forefront of innovative therapeutic development, is seeking an accomplished Principal Research Scientist to join their dynamic R&D team in **New York City, New York, US**. This critical role will lead and contribute to cutting-edge research initiatives focused on the discovery and preclinical development of novel drug candidates. You will leverage your extensive scientific expertise, state-of-the-art laboratory facilities, and collaborative environment to drive breakthrough discoveries. This position involves a hybrid work arrangement, blending impactful lab-based research with remote scientific analysis and collaboration.

Responsibilities: Design and execute complex experimental strategies to identify and validate novel drug targets and lead compounds. Lead research projects from target identification through lead optimization, contributing significantly to preclinical development. Develop and optimize innovative biochemical, cellular, and in vivo assays. Analyze experimental data, interpret results, and draw robust conclusions. Prepare high-quality research reports, manuscripts for publication, and presentations for scientific conferences. Collaborate effectively with multidisciplinary teams, including chemists, biologists, pharmacologists, and toxicologists. Mentor and guide junior scientists and research associates, fostering a collaborative and scientifically rigorous environment. Stay abreast of the latest scientific literature, technological advancements, and competitive landscape in relevant therapeutic areas. Contribute to the strategic direction of the drug discovery pipeline. Ensure compliance with all laboratory safety regulations and company policies. Qualifications: Ph.D. in Molecular Biology, Biochemistry, Pharmacology, Immunology, or a related life science discipline. Minimum of 8-10 years of post-doctoral and industry experience in drug discovery, with a strong track record of publications in peer-reviewed journals. Demonstrated expertise in one or more of the following areas: small molecule discovery, biologics development, genomics, proteomics, or translational research. Extensive experience in designing, performing, and troubleshooting complex biological assays. Proven ability to independently design, manage, and execute research projects. Strong analytical and critical thinking skills, with the ability to interpret complex datasets. Excellent communication, presentation, and interpersonal skills, with the ability to effectively collaborate within a team and present findings. Experience in mentoring junior researchers is highly desirable. Familiarity with bioinformatic tools and data analysis software. Knowledge of regulatory requirements for drug development is a plus. Join our client in **New York City, New York, US**, and contribute to the development of life-changing medicines in a stimulating and collaborative hybrid work setting.