Research Scientist, Antibody Discovery and Research

Overview

Research Scientist, Antibody Discovery and Research — Mapp Biopharmaceutical Inc

Join to apply for the Research Scientist, Antibody Discovery and Research role at Mapp Biopharmaceutical Inc.

Base pay range

$80,000.00/yr - $130,000.00/yr

Mapp Biopharmaceutical, Inc. "Mapp" is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.

The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio through CMC, Nonclinical, Regulatory, Project Management, and Clinical activities consistent with Mapp's product development objectives.

Responsibilities

• Optimizes and designs expression constructs for protein stability, solubility and expression levels
• Designs and optimizes strategies to generate and purify proteins of interest for subsequent in vitro and in vivo applications
• Designs and develops novel in vitro assays to assess antibodies for binding and activity
• Supervises research scientists at various levels as needed
• Reviews and synthesize new research findings regularly
• Maintains detailed records of all experiments performed
• Presents and communicates effectively experimental results to the group

Basic Qualifications

• PhD or equivalent in biology, molecular biology, biochemistry, virology, and/or related field
• Post doc experience or other appropriate scientific experience
• Author on scientific publications in respected peer reviewed journals
• Demonstrated excellence in the following competency areas:
• Protein expression in bacterial, mammalian and insect cell systems
• Protein purification, including experience with automated HPLC and FPLC systems, fluency in GE Unicorn FPLC software
• Flow cytometry and single B-cell sorting techniques
• Experience in leading scientific personnel to execute against program deliverables
• Experience with ForteBio Octet technology and isothermal titration calorimetry
• Hands-on experience operating IncuCyte and similar high-content live-cell imaging systems
• Experience effectively troubleshooting experimental strategies in the laboratory

Preferred Qualifications

• Experience with primer design and RT-PCR particularly for monoclonal antibody isolation and cloning from single B-cells
• Experience expressing and purifying viral proteins
• Experience with reverse genetics and pseudo typed viral vector systems
• Command of in-silico workflows for antibody and protein engineering and optimization
• Development of functional cell based assays/immunoassays to assess mechanism of action and potency of new antibody candidates (e.g. reporter assay, internalization assay, neutralization assay, shedding assay, ADCC/ADCP assays, multi-color flow)
• Generation of stable cell lines using lentivirus transduction and validation of those cell lines via flow cytometry and western blot

Mapp offers a competitive compensation and benefits package in addition to this exciting and challenging job. The pay scale for this position is $80,000 to $130,000 per year plus applicable bonuses. Medical, dental, and vision insurance benefits are available to eligible employees and their families. Mapp also provides basic life insurance, short and long term disability, and a 401K plan with company contributions. Full-time employees receive sick time, paid holidays, and vacation accrual.

This position is on-site at Mapp's San Diego facility. Travel: Domestic ~2x per year; International ~1x per year.

Equal Opportunity

Mapp is an equal opportunity employer and employment decisions are not based on protected status. Mapp uses E-Verify. Referrals increase your chances of interviewing at Mapp Biopharmaceutical Inc, but unsolicited solicitations are not welcome.

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