Scientist

We are partnering with a rapidly growing biotech startup in the Greater Boston area, developing advanced organ-on-a-chip and microphysiological systems to model human disease and accelerate drug discovery. This role is ideal for a scientist who thrives in a hands-on, fast-paced environment, is eager to take initiative, and is motivated by strong opportunities for technical ownership and career growth.

Requirements of the Scientist- Cell Biology:

• PhD in Cell Biology, Molecular Biology, Bioengineering, Chemical Engineering, or related field
• 1–3+ years experience developing complex in vitro models (e.g., organoids, 3D cultures, organ-on-chip, MPS)
• Hands-on experience with primary human cell culture and 3D tissue systems
• Strong proficiency in confocal and fluorescence microscopy in 3D tissue contexts
• Experience with immunoassays, molecular biology techniques, and gene/protein expression analysis
• Proficiency with image analysis platforms (e.g., FIJI/ImageJ, CellProfiler, Imaris)
• Experience with biomaterials, extracellular matrix systems, or tissue engineering approaches
• Familiarity with ADME/Tox, drug metabolism, hepatotoxicity, or nephrotoxicity assays
• Experience with data analysis and statistical software (e.g., GraphPad Prism, R)

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Responsibilities of the Scientist- Cell Biology:

• Design, develop, and validate 3D in vitro tissue models using biomaterials, scaffolds, and organ-on-chip platforms
• Perform primary human cell culture and tissue model experiments using molecular and cellular biology techniques
• Execute immunofluorescence (IF), immunohistochemistry (IHC), qPCR, and biochemical assays
• Conduct advanced imaging workflows, including confocal, fluorescence, electron, and high-content microscopy
• Analyze morphological and phenotypic endpoints using image analysis software (e.g., FIJI/ImageJ, CellProfiler, Imaris)
• Design and execute experiments; analyze and interpret experimental data
• Support development and optimization of microphysiological systems (MPS) and complex in vitro models
• Document experimental methods, results, and protocols; contribute to technical reports, manuscripts, and grant materials
• Train staff on specialized laboratory techniques and imaging workflows