Scientist/Sr. Scientist, iPSC Differentiation-MSC/β-cells/Neuron

Function: Research & Development

Job Location: Boston

At QLD Biotherapeutics, we develop cell and gene therapies using innovative technologies to treat devastating diseases. We are seeking a highly motivated and talented Scientist/Senior Scientist to join our Cellular Therapy Group to advance our efforts in induced-pluripotent stem cell (iPSC)-derived cell therapies. The successful candidate will focus on developing novel iPSC-β-cells or Neurons or MSC differentiation platform to support best-in-class cell therapy development.

This position provides an excellent learning and growth opportunity, to work closely with an experienced drug discovery and development team and contribute to early stages of research and development activities in a fast-paced and highly collaborative environment.

Primary Responsibilities

· Design and optimize novel, scalable and robust iPSC differentiation platforms to produce β-cells or neuronal cells or MSC with high efficiency and purity, for treatment of diabetes, neurological diseases or other related diseases.

· Develop and validate characterization assays to determine the various differentiation stages using cellular and molecular methods.

· Reprogram somatic and blood cells and bank corresponding iPSC clones.

· Perform genetic modifications using CRIPSR-Cas system and select the desired iPSC clones using phenotypic markers and genotyping.

· Analyze and interpret the data and be responsible for timely and effective communication of data and results to the project teams.

· Manage study progress, ensure data accuracy and integrity.

· Prepare key preclinical documents, and patent application, including, but not limited to study protocols, and study reports to support IND filling

· Identify potential project hurdles, suggest solutions, and contribute to contingency plans.

· Works collaboratively within internal cross-function teams and external CRO/academic institutes

· Adhere to the appropriate SOP and GxP guidelines, and embrace a collaborative culture

Qualification:

· PhD in developmental biology, immunology, cell biology, or related field with 3+ years of post-doctoral, academic faculty, or industrial experience

· Expertise at iPSC or stem cell differentiation, culture, banking and characterization

· Experience in cellular and gene engineering using CRISPR, lentivirus, transposon and LNP is preferred

· Experience with multiplex flow cytometry and whole genome sequencing is preferred

· Track record of independent research and creativity, as demonstrated by first author publications

· Excellent organizational and time management skills and must be a self-starter with the ability to thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment.

· Excellent verbal and written communication skills.

Please submit your resume to moyar.ge@qilu-pharma.com;