Senior Principal Research Scientist Engineering

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

R&D Process Engineering Organization, a part of AbbVie’s Development Sciences organization, is responsible for designing and developing scalable processes to make drug substances and drug products, including synthetics molecules, antibody drug conjugates (ADCs) and genetic medicines, throughout pre-clinical and clinical development stages. Process Engineering also partners with Biologics CMC (Chemistry, Manufacturing, and Controls) Development and Aesthetics R&D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products including toxins and cosmetic active ingredients (CAIs). It drives the development of innovative engineering technologies and creates valuable intellectual property through the composition of matter and chemical/bio-chemical processes resulting in cost-effective commercial manufacturing processes for quality products. Process Engineering organization also supports the scale-up in the pilot plants and supply chain development for pipeline molecules and supports the justification of CMC regulatory content.

Job Description

Role Overview

The successful Process Engineering candidate will play a key technical team leader role in the R&D Process Engineering function. In addition to a strong background in fundamentals of chemical engineering, the ideal candidate will have demonstrated experience in the biologics, peptides, ADC development and genetic medicines as a strong technical team leader. The candidate must have demonstrated initiative in building and sustaining cross-functional collaborations. In addition to leading the technical team, the successful candidate is also expected to lead the identification and development of novel approaches and technologies to enhance process development efficiency and commercialization of novel modalities. The candidate must exhibit a collaborative behavior in proactively identifying process challenges on a wide range of pipeline and innovation projects, take a leadership role in a cross-functional team to deliver specific project needs, and take on a scientific leadership role in developing and implementing solutions.

Key Responsibilities:

• Develop robust manufacturing processes, supporting assets including novel modalities through all phases of clinical development.
• Lead project teams towards process development and characterization of new synthetic and large molecule assets.
• Influence process development of toxins, cosmetic active ingredients and genetic medicines proactively.
• Lead scale-up of laboratory processes in the pilot plant.
• Set project strategies, define project responsibilities and timelines, and provide leadership in a matrixed team setting.
• Address challenging problems with biochemical reactions, separations, and/or isolations using expertise in reaction kinetics, transport phenomena, and mathematical modeling.
• Establish, communicate, and execute research plans.
• Exhibit a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively by multi-disciplinary interactions with organic chemists, analytical chemists, process development engineers, pilot plant engineers, drug product development scientists, program managers, and regulatory affairs specialists.
• Author and/or review technical documents summarizing process development efforts and contribute to regulatory filings.
• Strengthen scientific brand of Process Engineering while providing mentorship to direct reports and process engineering colleagues.

Qualifications

• BS, MS, or PhD in Chemical/Bio Engineering or a related field and 18+ (BS), 16+ (MS), or 10+ (PhD) years of relevant biopharmaceuticals industrial experience.
• Ph.D. candidates with pertinent research exposure are also encouraged to apply.
• Job level will be commensurate with academic and/or industrial work experience.
• Candidates are expected to have a strong foundations in chemical engineering and the proven ability to demonstrate their skills in this field.
• The candidate is expected to demonstrate the ability to solve challenging technical problems and champion next generation of innovative technologies to achieve project goals around novel modalities.
• The candidate is required to be a strong team player and demonstrate scientific leadership, possessing effective oral and written communication skills for