Senior Principal Scientist, Clinical and Biomarker Data Analytics (Neuroscience)

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Boston, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America

Job Description:

Johnson & Johnson, is recruiting for a Senior Principal Scientist, Clinical and Biomarker Data Analytics (Neuroscience) to be based at one of our sites in San Diego, CA; Titusville, NJ; Spring House, PA; or Boston, MA.

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Neuroscience team tackles the world's toughest brain health challenges including multiple sclerosis, Alzheimer's disease, Parkinson's disease, myasthenia gravis, epilepsy, major depressive disorder, bipolar disorder, schizophrenia, and autism. This patient-focused team helps address some of the most complex diseases of our time.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

The Neuroscience Precision Measures (PM) Team is an integrated scientific organization supporting the delivery of precision therapeutics to patients with CNS disorders across neuropsychiatry, neurodegeneration, and ophthalmology. The team brings together disease experts, biomarker scientists, computational biologists, and leaders in imaging and digital health, and partners closely with Neuroscience Discovery and Development organizations to advance an industryleading portfolio of novel mechanisms.

Precision Measures advances measurement science grounded in human data-including fluids, tissues, highdimensional biology, and neuroimaging-to support the endtoend portfolio. In close collaboration with internal and external partners, the organization delivers decisionenabling insights spanning target selection, early and late clinical development, regulatory submissions, and postmarket evidence generation.

The Senior Principal Scientist, Clinical and Biomarker Data Analytics is a senior individual contributor who serves as a scientific and analytical leader supporting neuroscience biomarker discovery, screening funnel optimization, and biomarker endpoint development from discovery through clinical development. Reporting to the Head of Quantitative Imaging and Clinical Biomarkers, the incumbent works in close partnership with Precision Measures and across Neuroscience functions on advanced quantitative and modeling approaches to enable robust biomarker strategies and development decisions.

Operating with minimal direction, the incumbent leads biomarkers analyses across disease areas and measurement modalities. The role requires independent scientific judgment and deep quantitative expertise to evaluate and validate biomarkers in their context of use. The incumbent serves as a key scientific authority on crossfunctional teams and contributes to biomarker strategy development, analytical evidence packages, and expert input.

Key Responsibilities

• Serve as a senior scientific leader for clinical and biomarker data analytics, partnering with Precision Measures and Neuroscience functions to drive data-informed biomarker strategy across discovery and development.

• Lead quantitative analyses supporting biomarker discovery, screening funnel performance, and endpoint development, ensuring analytical rigor and fitness-for-purpose in a clinical trial context.

• Apply advanced modeling and statistical methods to integrate multimodal biomarker data (e.g., imaging, fluid, clinical endpoints) and generate interpretable evidence to inform decision-making.

• Quantify and interpret relationships between biomarkers and clinical outcomes, supporting assessment of biomarker utility for enrichment, stratification, and endpoint development.

• Provide hands-on analytica