Senior Principal Scientist; Senior Director), Discovery and Translational Immunology

Position: Senior Principal Scientist (Senior Director), Discovery and Translational Immunology

Job Description

Our Company's Discovery Immunology groups are developing a world‑class pipeline to treat immune‑mediated diseases across Gastroenterology, Rheumatology and Dermatology. We are seeking an exceptional scientific leader with deep expertise in Immunology Discovery and Translational Research to join our vibrant Research & Discovery team in San Diego in our journey to discover and develop the next generation of best‑in‑class medicines that will raise the therapeutic ceiling in the treatment of immune‑driven diseases.

This role is equivalent to a Senior Director and will report to the Associate Vice President, Immunology Discovery. It will serve as Discovery Immunology Project lead on early‑stage immunology programs, driving projects from scientific rationale for target translational research, target validation, differentiation, de‑risking, modality selection, and overall strategy through the Discovery stages.

This scientific leader will also play a key role in building and executing the translational research strategy for Immunology. This is a strategic role that sits at the interface of Discovery, Biomarkers and Early Development, and will also interact and influence the design and execution of translational data generation from internal clinical studies. The individual will also play an important role in identifying, managing and executing translational research collaborations with academic scientific researchers and CROs.

Previous experience in translational science research with a focus on acquisition of disease patient samples and multi‑omics data generation and interpretation in collaboration with computational/Data science partners are key attributes.

Collaborating with Discovery Biologics, Chemistry, Quantitative Biology, Computational Scientists, Translational Medicine and other functions at Our Company, you will be defining and executing the discovery and translational strategy for multiple programs. The role also will be responsible for early discovery programs, translational data and biomarker discovery for portfolio pipeline programs in immunology and its successful and timely transition into Early Development.

Key Responsibilities

• Work with the Associate Vice President Immunology Discovery SD Research & Development Division and other project leads on site as well as other Research & Development Division Immunology Discovery sites to define and execute drug discovery immunology programs in the portfolio as part of the Immunology TA strategy.
• Closely collaborate with a cross‑functional group of experts across Our Company to design and execute the Research Operating Plan to advance projects through Discovery.
• Lead the discovery and creation of cellular, molecular and functional assays required for design and execution of the Research Operating Plan to advance projects through Discovery and toward early development.
• Partner closely with cross functional colleagues, including Computational Scientists (DAGS), modelers, PKPD, to advance projects forward through stages of Discovery.
• Lead the discovery and creation of cellular, molecular and functional assays that serve as biomarkers for prosecution of programs as they advance through the Discovery stages toward Early Development.
• Contribute to discovery and creation of translational data strategy for immunology including partnering internally and externally in the generation of actionable science packages to identify, validate and execute novel targets implicated in the pathogenesis of TA disease areas including diseases in the Derm, Rheum and GI areas.
• Collaborate with Translational Medicine and Biomarker colleagues for programs moving toward Early Development to ensure transition of early discovery biomarkers and biomarkers plans for execution during development stages.
• Champion the use of new technologies and modalities to drive discovery and prosecution of novel targets in immunological disease through various modalities and approaches including small molecules, peptides, biologics, T cell engagers and others.
• Actively contribute to the overall company's Immunology TA strategy.
• Maintaining awareness of scientific developments…