Opportunistic Role

Phylo

South San Francisco +1 more

Hybrid

Who this role is best for

A natural match if you have startup experience and a track record of building impactful projects. This mid-level role in South San Francisco emphasizes end-to-end ownership and AI-native problem-solving in a fast-moving, flat team structure focused on biomedical science.

Best fit for

Candidates with startup or founding-team experience in ambiguous, under-resourced environments
— “Startup or founding-team experience in an early, ambiguous, under-resourced environment”
Individuals who have personally built, shipped, or discovered something with measurable impact
— “A concrete track record of something you personally built, shipped, sold, or discovered”
People who thrive in a flat, fast-moving team and take initiative without being directed
— “the best people here define their own mandate rather than wait for one”

Things to consider

Requires regular in-office presence in South San Francisco for five days a week unless hybrid options are available
— “Able to be in our South San Francisco office five days a week”
No explicit mention of remote flexibility or hybrid options for all roles
— “some roles can be hybrid - tell us your constraints”

How to stand out

Emphasize your ability to take end-to-end ownership of projects in your resume and interviews
— “End-to-end ownership. You'll pick things up unprompted, diagnose before you design, and see them through.”
Highlight a specific project you built or discovered, ideally with a link to demonstrate impact
— “Send us a short blurb on what you're best at and one thing you've built, shipped, or discovered - and share a link.”
Demonstrate your AI-native instincts by showcasing how you've used AI to multiply your output or solve complex problems
— “AI-native: you use AI to multiply your output and have a strong instinct for where it's high-leverage.”

Pace · Fast PacedCollaboration · LowAutonomy · HighDecision Impact · IndividualLevel · Mid

Derived from job-description analysis by Serendipath's career intelligence engine.

What success looks like

define own mandate
work on real problems at the frontier of AI and biology

Typical background

AI/ML researchbiomedical science

Skills & requirements

Required

Ai-nativeHigh AgencyLow-egoEnd-to-end Ownership

Preferred

Genuine Interest In BiologyStartup ExperienceAi-native Team Experience

Stack & domain

AIMLCross-functional CollaborationBiomedical ScienceAI For Science

About the role

Original posting from Phylo via Ashby

About Phylo
Phylo is an applied research lab building agentic intelligence to accelerate discovery for every biomedical scientist. We believe AI agents will fundamentally transform how biomedical research is done. Our fast-growing team brings together researchers and engineers across AI and biology, commercializing the Biomni platform.
Our growing team brings together world class researchers and engineers across AI and biology. Backed by a $13.5M seed round led by a16z, Menlo Ventures and Anthropic, and advised by Nobel Prize laureate and pioneering biologists, Phylo is building the next generation of AI systems for the life sciences.
About the Role
We don't always have the perfect role posted for every exceptional person - but we're always looking for them. If you're excited about applying frontier AI to real biomedical science and you don't see a title that fits, apply here to reach us!
Send us a short blurb on what you're best at and one thing you've built, shipped, or discovered - and share a link.
What You'll Work On:
Whatever you're exceptional at. We're a flat, fast-moving team, and the best people here define their own mandate rather than wait for one.
Real problems at the frontier of AI and biology - from the agent platform itself to the science, infrastructure, product, and commercial work that gets it into the hands of scientists.
End-to-end ownership. You'll pick things up unprompted, diagnose before you design, and see them through.
Requirements:
High agency: you handle things end-to-end and don't need a playbook handed to you.
AI-native: you use AI to multiply your output and have a strong instinct for where it's high-leverage.
Low-ego, can-do, and easy to work with.
A concrete track record of something you personally built, shipped, sold, or discovered. We care more about demonstrated ability than a particular credential.
Able to be in our South San Francisco office five days a week (some roles can be hybrid - tell us your constraints).
Nice to Haves:
Genuine interest in biology, drug discovery, or AI for science.
Startup or founding-team experience in an early, ambiguous, under-resourced environment.
Experience on AI-native teams that use coding agents and automation extensively.
Why Join Us?
Competitive salary and equity share in building the future of biomedical discovery
Full medical, dental, and vision coverage, including free therapy sessions and eyewear stipend
401(k) to help you build long-term financial security (US only)
Unlimited PTO to recharge when you need it (US only)
Lunch and snacks when you're in the office
Regular team offsites and company events
A culture of excellence and speed - we move fast, think big, and support each other every step of the way
Your work will directly impact our mission to 100X biomedical discoveries through AI

Source: Phylo careers (Ashby)