Candidates with extensive medicinal chemistry experience and a track record of innovation will find this senior role in a collaborative, AI-integrated drug discovery environment in The Woodlands, Texas.
Derived from job-description analysis by Serendipath's career intelligence engine.
Original posting from Nurix via Greenhouse
Senior Scientist, Medicinal Chemistry
Drive medicinal chemistry strategy for Nurix's discovery programs, from hit optimization through development candidate nomination. You'll design novel compounds, interpret complex SAR across multidisciplinary datasets, and help set new scientific directions, with opportunities to lead chemistry workstreams and mentor colleagues.
Position Description
The Opportunity
Design novel chemical entities and medicinal chemistry strategies, applying structure-based drug design to optimize potency, selectivity, physicochemical properties, ADME/PK, safety, and in vivo efficacy
Design synthetic strategies for complex molecules using modern and creative synthetic methods
Develop and interpret SAR by integrating chemical, structural, computational, biochemical, cellular, pharmacological, and ADME/PK data; independently identify key questions, design experiments, and recommend compound or series advancement, redesign, or termination
Partner closely with computational chemists, structural biologists, and colleagues across biology, pharmacology, and DMPK to advance project objectives
Develop innovative concepts that establish new directions and address complex challenges, drawing on emerging literature, patents, and competitive intelligence to inform compound design and strategy
Lead chemistry workstreams within multidisciplinary teams, independently manage priorities and external collaborations, and contribute to project strategy and key scientific decisions
Provide scientific guidance, coaching, and mentorship to other scientists
Communicate scientific rationale, data, and recommendations clearly to project teams, leadership, and broader scientific audiences
Contribute to intellectual property generation, patent preparation, and scientific publications; represent assigned projects at external forums; and lead improvements in laboratory practices and workflows
What You’ll Bring
BS or MS with 14+ years of relevant experience, or PhD with 8+ years of relevant experience
Strong expertise in medicinal chemistry and synthetic organic chemistry, with demonstrated ability to apply synthetic strategies to complex discovery challenges, including compound design, SAR development, multiparameter optimization, and structure-based drug design in close collaboration with computational chemistry and structural biology
Ability to integrate potency, selectivity, structural, physicochemical, ADME/PK, and pharmacology data, with a solid understanding of biology and pharmacology, to guide compound design and project strategy
Scientific creativity and a track record of innovation, including advancement of chemical series, advanced leads, or development candidates
Strong problem-solving and project management skills: identifying critical questions, forming hypotheses, designing experiments, and translating results into actionable strategies across projects of significant scope and complexity
Ability to establish new chemical, scientific, or strategic directions from experimental data, structural insights, literature, patents, and emerging science, and to influence decisions within multidisciplinary teams
Experience providing scientific guidance, coaching, or mentorship, with strong skills in applying literature, patent, and competitive intelligence to program strategy
Excellent written and verbal communication skills for multidisciplinary teams, senior leadership, and external audiences
Salary Range: $147,500 - $157,500
The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location: Onsite – The Woodlands, TX
Fit with Nurix Culture and Values
Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Source: Nurix careers (Greenhouse)